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M94A2983.TXT
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1994-10-25
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Document 2983
DOCN M94A2983
TI Development of oral lesions in sexually and parenterally HIV-1 infected
persons. The Oral AIDS Center Epidemiology Group.
DT 9412
AU Hilton JF; Lifson AR; Canchola AJ; Greenspan D; Greenspan JS; University
of California, San Francisco.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):180 (abstract no. PB0145). Unique
Identifier : AIDSLINE ICA10/94369592
AB OBJECTIVE: (1) To compare incidence of oral lesions among HIV-1 infected
persons by route of transmission of HIV (sexual or parenteral). (2) To
estimate the effect of oral lesions by group on the incidence of AIDS.
METHODS: We examined 76 HIV-1 infected homosexual men and 72 men and 24
women infected through contaminated blood products (59% hemophiliacs,
41% transfusion recipients; TRs). Each underwent semi-annual oral exams
(for candidiasis and hairy leukoplakia), H&P, and measurement of CD4
counts, from soon after infection till Dec 1993 or loss to follow-up. We
estimated incidence using proportional hazards and Kaplan-Meier methods,
adjusted for missed exams and changing CD4 counts. RESULTS: At baseline
(July 1987), 89% of subjects had CD4 counts > 200 cells/microliters. All
homosexuals were 18-64 years of age, while 78% of hemophiliacs and 62%
of TRs were in this age group. Parenterally-infected subjects developed
oral candidiasis sooner than homosexual men (p = .04), but developed
hairy leukoplakia slightly later than these subjects (p > .20). Relative
hazards for AIDS due to oral lesions will also be reported. CONCLUSIONS:
These findings indicate that the risks of specific oral lesions depend
on route of HIV-1 transmission, having implications for management of
HIV disease in women and children as well.
DE Adolescence Adult AIDS-Related Opportunistic
Infections/*COMPLICATIONS/DIAGNOSIS/ TRANSMISSION Blood Component
Transfusion Candidiasis, Oral/*COMPLICATIONS/DIAGNOSIS/TRANSMISSION
Female *Homosexuality Human HIV
Infections/*COMPLICATIONS/DIAGNOSIS/TRANSMISSION *HIV-1 Leukoplakia,
Oral/*COMPLICATIONS/DIAGNOSIS Male Middle Age Risk Factors Sex
Behavior Substance Abuse, Intravenous/*COMPLICATIONS Support, U.S.
Gov't, P.H.S. MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).